Description

3-Acetyl-4-(3,4-Difluorophenyl)-6-Fluoroquinolin-2(1H)-One is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone and related therapeutic classes. It is essential for research and development chemists and manufacturers in the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the research and commercial synthesis of novel fluoroquinolone antibiotics and other small-molecule drugs.
• API Development: Serves as a core scaffold for developing new active pharmaceutical ingredients with potential antibacterial, anticancer, or other therapeutic activities.
• Chemical Research: Used in academic and industrial R&D laboratories for structure-activity relationship (SAR) studies and medicinal chemistry programs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to create complex, fluorinated heterocyclic compounds for various high-value applications.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	3-Acetyl-4-(3,4-Difluorophenyl)-6-Fluoroquinolin-2(1H)-One
CAS No.	1283109-72-7
Molecular Formula	C₁₇H₁₀F₃NO₂
Molecular Weight	329.27 g/mol
Synonyms	3-Acetyl-4-(3,4-difluorophenyl)-6-fluoro-1H-quinolin-2-one; 6-Fluoro-3-acetyl-4-(3,4-difluorophenyl)-2(1H)-quinolinone; 4-(3,4-Difluorophenyl)-6-fluoro-3-acetyl-2(1H)-quinolinone; 3-Acetyl-4-(3,4-difluorophenyl)-6-fluoroquinolin-2-ol; 1283109-72-7; 3-Acetyl-4-(3,4-difluorophenyl)-6-fluoro-2-quinolinone
EINECS	Contact for details

Quality Control

Our 3-Acetyl-4-(3,4-Difluorophenyl)-6-Fluoroquinolin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.