Description

Rhosin (Hydrochloride) CAS NO 1281870-42-5 is a high-purity, small molecule inhibitor specifically designed for research and development applications. This compound is valued for its role as a potent and selective inhibitor of RhoA-mediated signaling pathways, which are critical in cellular processes such as cytoskeletal dynamics and cell migration. It is an essential tool for researchers and developers in the fields of pharmaceutical discovery, cell biology, and biochemical research, where precise modulation of Rho GTPase activity is required.

Application

Rhosin (Hydrochloride) serves as a key biochemical tool in advanced research and development. Its primary applications include:

• Biochemical Research: Used as a selective RhoA inhibitor to study GTPase signaling mechanisms and protein-protein interactions in vitro.
• Cell Biology Studies: Applied in cell culture to investigate the role of RhoA in cytoskeleton reorganization, cell adhesion, and motility.
• Drug Discovery & Pharmacology: Serves as a reference compound and a starting point for the development of novel therapeutics targeting Rho-associated pathways in diseases like cancer and neurological disorders.
• Academic & Industrial R&D: A critical reagent for basic research in university laboratories and for target validation in biotech and pharmaceutical company pipelines.

Basic Information

Product Name	Rhosin (Hydrochloride)
CAS No.	1281870-42-5
Molecular Formula	C₂₀H₂₀ClN₃O₃ • HCl
Molecular Weight	422.31 g/mol (for hydrochloride salt)
Synonyms	Rhosin HCl; Rhosin hydrochloride; G04; 1-(3,4-Dihydroxyphenyl)-2-[(4-[(2-methyl-1H-imidazol-1-yl)methyl]phenyl)amino]-1-ethanone hydrochloride; RhoA inhibitor Rhosin; (2-(4-((2-Methyl-1H-imidazol-1-yl)methyl)phenylamino)-2-oxo-1-(3,4-dihydroxyphenyl)ethyl)phosphonic acid hydrochloride (common parent name)
EINECS	Contact for details

Quality Control

Our Rhosin (Hydrochloride) is manufactured under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.