Description

5-Cyano-Pyrazine-2-Sulfonyl Chloride is a high-value, reactive sulfonyl chloride derivative used as a key synthetic intermediate in advanced organic chemistry. Its core value lies in enabling the efficient introduction of the sulfonamide functional group, a critical pharmacophore in modern drug discovery. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating sulfonamide-based inhibitors and ligands.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel sulfonamide-containing drug candidates, including kinase inhibitors, antimicrobials, and enzyme modulators.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides that utilize the sulfonamide moiety for enhanced biological activity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) to study enzyme function and mechanism.
• Material Science Research: Employed in the creation of functionalized polymers or organic electronic materials where the sulfonamide group can modify material properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Cyano-Pyrazine-2-Sulfonyl Chloride
CAS No.	1279820-45-9
Molecular Formula	C5H2ClN3O2S
Molecular Weight	203.61 g/mol
Synonyms	5-Cyanopyrazine-2-sulfonyl chloride; 2-Pyrazinesulfonyl chloride, 5-cyano-; Pyrazine-2-sulfonyl chloride, 5-cyano-; 5-CN-Pyrazine-2-SO2Cl
EINECS	Contact for details

Quality Control

Every batch of 5-Cyano-Pyrazine-2-Sulfonyl Chloride is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical intermediates, ensuring traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.