Description

Fosinoprilat-D7 is a high-purity, deuterium-labeled internal standard critical for advanced quantitative bioanalytical studies. This stable isotope-labeled compound is essential for ensuring the accuracy, precision, and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in cardiovascular drug development and regulatory submissions.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a deuterated internal standard for the precise quantification of Fosinopril and its active metabolite, Fosinoprilat, in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic (PK) and Bioequivalence Studies: Enables accurate measurement of drug concentration-time profiles to support clinical trials and regulatory filings for ACE inhibitor medications.
• Drug Metabolism and Disposition Research: Facilitates studies on the absorption, distribution, metabolism, and excretion (ADME) of Fosinopril, aiding in metabolite identification and profiling.
• Biomarker Analysis and Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust analytical methods for monitoring drug levels in patients.
• Quality Control in Reference Material Production: Serves as a critical component in the preparation and certification of certified reference materials (CRMs) for analytical laboratories.

Basic Information

Product Name	Fosinoprilat-D7
CAS No.	1279220-43-7
Molecular Formula	C30H39D7NO6P
Molecular Weight	564.70 g/mol (for deuterated form)
Synonyms	(4S)-4-Cyclohexyl-1-[[(R)-[[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline-D7; Fosinoprilat (deuterated, D7); Fosinoprilat-d7; (S)-Fosinoprilat-D7; L-Proline, 4-cyclohexyl-1-[[(R)-[[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-, D7-labeled; Deuterated Fosinoprilat Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Fosinoprilat-D7 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from NMR, HPLC, and mass spectrometry. We adhere to relevant industry guidelines for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chemical Purity (by HPLC)	≥ 95.0%
Isotopic Enrichment (by MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.