Description

5-(3,4-Dimethyl-5-Isoxazolyl)-2-Thiophenesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate and versatile sulfonyl chloride reagent. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and functional materials, offering a unique heterocyclic scaffold for molecular diversification. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new therapeutic agents or high-performance materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry research targeting new therapeutic areas.
• Sulfonamide Synthesis: Acts as a crucial reagent for introducing the sulfonamide functional group, a common pharmacophore in many FDA-approved drugs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic sulfonyl motifs.
• Material Science: Serves as a precursor for functional polymers and advanced materials where the sulfonyl chloride group enables further chemical modification.
• Chemical Biology Probes: Utilized in creating activity-based probes and bioconjugation reagents for studying biological processes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences sector.

Basic Information

Product Name	5-(3,4-Dimethyl-5-Isoxazolyl)-2-Thiophenesulfonyl Chloride
CAS No.	1279219-52-1
Molecular Formula	C9H8ClNO3S2
Molecular Weight	277.75 g/mol
Synonyms	5-(3,4-Dimethylisoxazol-5-yl)thiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-(3,4-dimethyl-5-isoxazolyl)-; 5-(3,4-Dimethyl-1,2-oxazol-5-yl)thiophene-2-sulfonyl chloride; 5-(3,4-Dimethylisoxazole-5-yl)thiophene-2-sulfonyl chloride; 5-(3,4-Dimethyl-5-isoxazolyl)-2-thienylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-(3,4-Dimethyl-5-Isoxazolyl)-2-Thiophenesulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.