Description

2-Chloro-5-(Trifluoromethyl)Nicotinamide is a high-value, multi-functional chemical intermediate characterized by its unique pyridine core substituted with chloro and trifluoromethyl groups. This compound matters for its role as a critical building block in the synthesis of advanced agrochemicals and active pharmaceutical ingredients (APIs), where its structural motifs confer desirable biological activity and metabolic stability. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor research and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new chemical entities and reaction pathways in heterocyclic chemistry.
• Material Science: Potential application as a building block for functional materials, such as ligands for catalysts or components in organic electronics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Nicotinamide
CAS No.	1279217-36-5
Molecular Formula	C7H4ClF3N2O
Molecular Weight	224.57 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)pyridine-3-carboxamide; Nicotinamide, 2-chloro-5-(trifluoromethyl)-; 3-Pyridinecarboxamide, 2-chloro-5-(trifluoromethyl)-; 2-Chloro-5-trifluoromethylnicotinamide; 2-Chloro-5-(trifluoromethyl)-3-pyridinecarboxamide
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.