Description

n-Acetyl-S-Methyl-L-Cysteine-D3 is a stable isotope-labeled derivative of the endogenous antioxidant and detoxification agent, N-acetylcysteine. This compound is specifically deuterated, making it an essential internal standard for precise quantitative analysis in mass spectrometry-based research. It is primarily utilized by analytical chemists and researchers in pharmaceutical development and clinical diagnostics who require high-fidelity measurement of metabolic pathways and drug disposition. The product is supplied under stringent quality control to ensure isotopic purity and chemical stability for sensitive applications.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of N-acetylcysteine and its metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for pharmaceuticals containing or metabolizing to cysteine derivatives.
• Biomarker Research: Used in assays investigating oxidative stress markers, glutathione metabolism, and related clinical biomarkers.
• Stable Isotope Dilution Analysis (SIDA): Provides the reference point for this gold-standard method in quantitative mass spectrometry, ensuring high accuracy and reproducibility.
• Pharmaceutical Quality Control: Supports method development and validation for the analysis of cysteine-based active pharmaceutical ingredients (APIs) and finished products.

Basic Information

Product Name	n-Acetyl-S-Methyl-L-Cysteine-D3
CAS No.	1279039-06-3
Molecular Formula	C6H8D3NO3S
Molecular Weight	178.22 g/mol (for deuterated form)
Synonyms	N-Acetyl-S-methyl-L-cysteine-d3; (2R)-2-Acetamido-3-[(methyl-d3)sulfanyl]propanoic acid; S-Methyl-N-acetyl-L-cysteine-d3; N-Acetyl-3-[(methyl-d3)thio]-L-alanine; SMAC-d3; NAC-S-Me-d3; Acetylcysteine S-methyl ester-d3; Stable Isotope Labeled N-Acetyl-S-Methylcysteine
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-S-Methyl-L-Cysteine-D3 is manufactured and analyzed to meet exacting standards for isotopic enrichment and chemical purity. Our quality assurance includes comprehensive testing via NMR, HPLC, and mass spectrometry to confirm deuterium incorporation, chiral purity, and absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the assay, isotopic purity, and chromatographic profile. Our processes are designed to support research requiring regulatory compliance, including GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage over 12 months, storing at 2-8°C is recommended to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium)	≥ 98 atom % D
Isomeric Purity (Chiral HPLC)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.