Description

Scopolamine-D3 Hydrobromide is a deuterium-labeled isotopologue of the well-known anticholinergic agent, scopolamine hydrobromide. This high-purity stable isotope-labeled compound is essential for precise quantitative analysis in pharmacokinetic and metabolic studies, ensuring data accuracy and reliability. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in advanced drug development and bioanalytical research.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the accurate quantification of scopolamine in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used as a reference standard to develop, optimize, and validate sensitive and specific mass spectrometry-based assays.
• Doping Control and Forensic Analysis: Supports accurate detection and confirmation of scopolamine in forensic toxicology and anti-doping programs.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques to minimize matrix effects and improve analytical precision.
• Pharmaceutical Quality Control: Acts as a reference material in the quality control of scopolamine-based pharmaceutical formulations.

Basic Information

Product Name	Scopolamine-D3 Hydrobromide
CAS No.	1279037-70-5
Molecular Formula	C17H18D3NO4 • HBr
Molecular Weight	386.29 g/mol (approx.)
Synonyms	(-)-Scopolamine-D3 Hydrobromide; Hyoscine-D3 Hydrobromide; 6β,7β-Epoxy-1αH,5αH-tropan-3α-ol(-)-tropate-D3 Hydrobromide; Scopolamine-d3 HBr; Deuterated Scopolamine HBr; [2H3]-Scopolamine Hydrobromide; L-Hyoscine-D3 Hydrobromide
EINECS	Contact for details

Quality Control

Our Scopolamine-D3 Hydrobromide is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic methods. We adhere to cGMP principles for the production of reference standards, supporting compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.