Description

(R)-(-)-Phenylephrine-D3 Hcl is a deuterium-labeled isotopologue of the pharmaceutical agent phenylephrine hydrochloride, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise measurement of phenylephrine levels.

Application

• Internal Standard for LC-MS/MS: Primary application for the quantitative bioanalysis of phenylephrine in plasma, serum, and urine samples.
• Pharmaceutical R&D: Used in pharmacokinetic and metabolism studies to track drug absorption, distribution, and excretion.
• Forensic Toxicology: Enables accurate quantification of phenylephrine in forensic casework and doping control analysis.
• Clinical Research: Supports studies investigating drug efficacy, safety profiles, and patient adherence.
• Method Development & Validation: Critical for developing and validating robust, regulatory-compliant analytical methods (e.g., for FDA/EMA submissions).
• Quality Control (QC) Testing: Used in pharmaceutical manufacturing QC to ensure batch consistency and purity of phenylephrine-containing products.

Basic Information

Product Name	(R)-(-)-Phenylephrine-D3 Hydrochloride
CAS No.	1276197-50-2
Molecular Formula	C9H10D3NO2•HCl
Molecular Weight	207.69 g/mol
Synonyms	(R)-(-)-Phenylephrine-D3 HCl; (R)-3-[2-(Methyl-d3-amino)-1-hydroxyethyl]phenol hydrochloride; (1R)-1-(3-Hydroxyphenyl)-2-[(methyl-d3)amino]ethanol hydrochloride; Phenylephrine-d3 (hydrochloride); Deuterated Phenylephrine HCl; Phenylephrine Internal Standard; L-Phenylephrine-d3 hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-(-)-Phenylephrine-D3 HCl is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from NMR (Nuclear Magnetic Resonance), HPLC (High-Performance Liquid Chromatography), and MS (Mass Spectrometry) analyses. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable, ensuring traceability and reliability for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.