Description

(±)-Carazolol-D7 Hcl (iso-Propyl-D7) is a deuterated isotopologue of the non-selective β-adrenergic receptor antagonist Carazolol, where seven hydrogen atoms are replaced by deuterium, specifically on the isopropyl moiety. This compound is a critical analytical standard used for precise quantification and metabolic studies in pharmaceutical research and development. It is primarily required by researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors for use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and other advanced analytical techniques.

Application

• Primary use as an Internal Standard (IS) for the accurate quantification of Carazolol in biological matrices (e.g., plasma, serum, urine) via LC-MS/MS.
• Essential for conducting pharmacokinetic and metabolic stability studies during drug development, enabling precise tracking of the parent compound.
• Facilitates deuterium isotope effect studies to investigate metabolic pathways and enzyme mechanisms.
• Supports bioanalytical method development and validation in compliance with regulatory guidelines (e.g., FDA, EMA).
• Used in reference material production for calibrating analytical instruments and ensuring data integrity.
• Applied in veterinary pharmaceutical research, as Carazolol is also used in animal health.

Basic Information

Product Name	(±)-Carazolol-D7 Hcl (iso-Propyl-D7)
CAS No.	1276197-44-4
Molecular Formula	C18H15D7ClN2O2
Molecular Weight	~333.88 g/mol
Synonyms	Carazolol-d7; 1-(Carbazol-4-yloxy)-3-[(1-methylethyl-d7)amino]-2-propanol Hydrochloride; 4-[2-Hydroxy-3-[(2-propan-d7-yl)amino]propoxy]carbazole Hydrochloride; DL-Carazolol-d7 Hydrochloride; (±)-Carazolol-d7 HCl; Carazolol (isopropyl-d7) hydrochloride; Carazolol D7
EINECS	Contact for details

Quality Control

Every batch of (±)-Carazolol-D7 Hcl (iso-Propyl-D7) is manufactured and analyzed under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed data on purity, isotopic purity (D-enrichment), and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.