Description

Ritalinic-D9 Acid Hcl (Piperidine-D9) (Mixture Of Stereoisomers) is a deuterated isotopologue of ritalinic acid hydrochloride, a key metabolite of methylphenidate. This compound is specifically designed for use as an internal standard in analytical chemistry, providing unmatched accuracy for quantitative analysis. It is an essential material for pharmaceutical research, forensic toxicology, and clinical laboratories requiring precise measurement of methylphenidate and its metabolites. The product is supplied as a mixture of stereoisomers to match the metabolic profile of the parent drug.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity, isotopically labeled internal standard for the accurate quantification of methylphenidate and ritalinic acid in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies, metabolism investigations, and bioequivalence testing for stimulant medications.
• Forensic and Clinical Toxicology: Critical for developing and validating sensitive and specific analytical methods to detect and confirm the presence of methylphenidate in workplace drug testing, doping control, and post-mortem analyses.
• Reference Standard: Serves as a certified reference material (CRM) for method development, calibration, and quality control in analytical laboratories.
• Metabolite Studies: Enables detailed research into the metabolic pathways and clearance mechanisms of methylphenidate in both human and animal models.
• Regulatory Submissions: Supports data packages submitted to regulatory bodies (e.g., FDA, EMA) by providing traceable and reliable analytical data.

Basic Information

Product Name	Ritalinic-D9 Acid Hcl (Piperidine-D9) (Mixture Of Stereoisomers)
CAS No.	1276197-13-7
Molecular Formula	C14H10D9ClNO2
Molecular Weight	Approx. 267.8 g/mol
Synonyms	Ritalinic Acid-d9 Hydrochloride; α-Phenyl-2-piperidineacetic-d9 Acid Hydrochloride; Methylphenidate Acid Metabolite-d9 HCl; DL-Threo-Methylphenidate Acid-d9 Hydrochloride; 2-Piperidineacetic-d9 Acid, α-Phenyl-, Hydrochloride; Ritalinic-d9 Acid; PIPD9A HCl; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of Ritalinic-D9 Acid Hcl (Piperidine-D9) is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and Mass Spectrometry to confirm deuteration level and structural identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.