Description

2-(1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-2-Yl)Ethanamine is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonamide-piperidine-pyridine scaffold. This compound is critical for medicinal chemistry research and development, offering a versatile building block for constructing novel small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of targeted drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a core scaffold or a functionalized fragment in hit-to-lead and lead optimization campaigns for drug discovery programs.
• Protease Inhibitor Development: The sulfonamide and piperidine motifs make it a valuable candidate for designing inhibitors of various enzymes, including kinases and proteases.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological pathways and target validation.
• Custom Synthesis Building Block: Provides a fluorinated, nitrogen-rich heterocyclic core for contract research organizations (CROs) and custom synthesis manufacturers.
• Process Chemistry Scale-Up: Used in route scouting and optimization for the scalable, GMP-compliant production of investigational new drugs.

Basic Information

Product Name	2-(1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-2-Yl)Ethanamine
CAS No.	1274746-15-4
Molecular Formula	C12H18FN3O2S
Molecular Weight	287.35 g/mol
Synonyms	2-[1-[(5-Fluoropyridin-3-yl)sulfonyl]piperidin-2-yl]ethanamine; 2-(1-(5-Fluoropyridine-3-sulfonyl)piperidin-2-yl)ethan-1-amine; 2-(1-(5-Fluoro-3-pyridylsulfonyl)piperidin-2-yl)ethylamine; 5-Fluoro-3-[(2-(2-aminoethyl)piperidin-1-yl)sulfonyl]pyridine; 1274746-15-4; 2-(1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-2-Yl)Ethan-1-Amine
EINECS	Contact for details

Quality Control

Our 2-(1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-2-Yl)Ethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR, MS) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.