Description

Rock-Ii Inhibitor CAS NO 1273579-40-0 is a specialized small molecule compound designed to selectively inhibit the Rho-associated coiled-coil containing protein kinase (ROCK-II), a key regulator of the actin cytoskeleton. This targeted inhibition is crucial for modulating cellular processes such as cell adhesion, motility, and contraction. It is an essential research tool for scientists in pharmacology, cell biology, and neuroscience, and holds significant potential for the development of therapeutics targeting cardiovascular diseases, neurological disorders, and cancer metastasis.

Application

• Biomedical Research: A critical tool for studying ROCK-II signaling pathways, cytoskeletal dynamics, and cell morphology in vitro.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening and lead optimization for diseases involving aberrant Rho/ROCK signaling.
• Neuroscience Studies: Investigation of axonal growth, growth cone collapse, and neural regeneration following injury.
• Cardiovascular Research: Exploration of vascular smooth muscle cell contraction, blood pressure regulation, and potential anti-hypertensive mechanisms.
• Oncology Research: Study of cancer cell invasion, metastasis, and the role of the tumor microenvironment.
• Ophthalmic Research: Investigation into intraocular pressure regulation and potential treatments for glaucoma.

Basic Information

Product Name	Rock-Ii Inhibitor
CAS No.	1273579-40-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ROCK-II Inhibitor; Rho Kinase II Inhibitor; ROCK2 Inhibitor; (S)-2-(2-(Difluoromethoxy)phenyl)-1-(4-((3-oxomorpholino)methyl)phenyl)-5-(trifluoromethyl)-1H-imidazole-4-carboxamide; CAS 1273579-40-0
EINECS	Contact for details

Quality Control

Our Rock-Ii Inhibitor is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade material standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.