Description

Hexahydrophenyl Cinacalcet Hydrochloride CAS NO 1271930-12-1 is a high-purity pharmaceutical intermediate, specifically a key derivative of the calcimimetic agent Cinacalcet. This compound is of critical importance for the development and manufacturing of active pharmaceutical ingredients (APIs) targeting calcium-sensing receptors. It is primarily needed by pharmaceutical R&D laboratories and API manufacturers engaged in the production of treatments for secondary hyperparathyroidism and related metabolic bone disorders.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Cinacalcet hydrochloride and its advanced analogs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key precursor in the research and scale-up of new calcimimetic drug candidates.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical products.
• Process Chemistry & Optimization: Employed in route scouting and process refinement for more efficient and cost-effective API manufacturing.
• Academic & Contract Research: Utilized in biochemical and pharmacological studies to investigate calcium receptor modulation.

Basic Information

Product Name	Hexahydrophenyl Cinacalcet Hydrochloride
CAS No.	1271930-12-1
Molecular Formula	C22H28F3N • HCl
Molecular Weight	407.92 g/mol (Free base: 371.46 g/mol)
Synonyms	N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride (Hexahydrophenyl derivative); Cinacalcet hexahydrophenyl analog HCl; (R)-N-(1-Naphthyl)ethyl-3-(3-trifluoromethylphenyl)propylamine hydrochloride (cyclic form); AMG 073 derivative; Sensipar® intermediate; Calcimimetic intermediate; (1R)-1-(Naphthalen-1-yl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)ethan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our Hexahydrophenyl Cinacalcet Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical R&D and advanced synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.