Description

Mi-2 (Menin-MLL Inhibitor) is a potent and selective small molecule inhibitor of the protein-protein interaction between Menin and Mixed Lineage Leukemia (MLL) proteins. This compound is a critical research tool for investigating the molecular pathways involved in MLL-rearranged leukemias and other cancers where this interaction plays a key oncogenic role. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and target validation.

Application

• Oncology Research & Drug Discovery: A key biochemical tool for studying the role of the Menin-MLL interaction in leukemia pathogenesis and for screening potential therapeutic agents.
• Target Validation Studies: Used in cellular and animal models to validate the Menin-MLL axis as a druggable target for cancer therapy.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) assays designed to identify novel inhibitors.
• Mechanism of Action (MOA) Studies: Enables detailed investigation into downstream signaling pathways and epigenetic regulation mediated by the Menin-MLL complex.
• Preclinical Proof-of-Concept: Supports in vitro and in vivo efficacy studies for developing novel therapeutic strategies against MLL-rearranged and NPM1-mutant leukemias.

Basic Information

Product Name	Mi-2 (Menin-MLL Inhibitor)
CAS No.	1271738-62-5
Molecular Formula	C₂₄H₂₈N₄O₃
Molecular Weight	420.51 g/mol
Synonyms	MI-2; MI 2; MI-2 (Menin inhibitor); VU0463294; 5-[(5-Chloro-2-thienyl)sulfonyl]-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide; Menin-MLL Interaction Inhibitor MI-2; VU 0463294; VU-0463294
EINECS	Contact for details

Quality Control

Every batch of Mi-2 (Menin-MLL Inhibitor) is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with our stringent in-house specifications. Our quality commitment supports reliable and reproducible results in your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular mass
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.