Description

Mi-3 (Menin-MLL Inhibitor) is a potent and selective small molecule inhibitor targeting the protein-protein interaction between Menin and Mixed Lineage Leukemia (MLL) proteins. This compound matters as a critical research tool for advancing the understanding and therapeutic targeting of MLL-rearranged leukemias, which are associated with poor prognosis. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, epigenetics, and targeted cancer therapy development. The product is supplied under the CAS registry number 1271738-59-0.

Application

• Oncology Research: A key biochemical tool for studying the role of the Menin-MLL interaction in leukemia pathogenesis and progression.
• Drug Discovery & Development: Used as a reference standard or lead compound in high-throughput screening and medicinal chemistry programs targeting epigenetic regulators.
• Mechanistic Studies: Enables investigation of downstream signaling pathways and gene expression changes in MLL-fusion protein-driven cancers.
• Preclinical Validation: Supports in vitro and in vivo studies to validate Menin inhibition as a viable therapeutic strategy for acute leukemias.
• Biomarker Research: Facilitates research into patient stratification and resistance mechanisms associated with Menin-MLL targeted therapies.

Basic Information

Product Name	Mi-3 (Menin-MLL Inhibitor)
CAS No.	1271738-59-0
Molecular Formula	C₂₄H₂₅ClN₄O₃
Molecular Weight	452.93 g/mol
Synonyms	MI-3; Menin-MLL inhibitor MI-3; (E)-N-((1-(4-Chlorophenyl)cyclopropyl)methyl)-3-((5-(pyridin-3-yl)pyridin-2-yl)amino)acrylamide; VU0463294; 2-Propenamide, N-[[1-(4-chlorophenyl)cyclopropyl]methyl]-3-[[5-(3-pyridinyl)-2-pyridinyl]amino]-, (2E)-
EINECS	Contact for details

Quality Control

Every batch of Mi-3 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research use. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, NMR, and MS data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.