Description

Spadin CAS NO 1270083-24-3 is a selective, potent, and non-peptide antagonist of the TREK-1 potassium channel. This compound is a critical research tool for neuroscientists and pharmacologists investigating pain pathways, depression, and neuroprotection. It is primarily utilized in academic, pharmaceutical, and biotechnology R&D for target validation and mechanistic studies in central nervous system disorders.

Application

• Neuroscience Research: Fundamental studies on the role of TREK-1 channels in neuronal excitability and signaling.
• Pain Mechanism Investigation: Used as a pharmacological tool to explore TREK-1's involvement in nociception and to identify novel analgesic targets.
• Antidepressant Research: Evaluation of the link between TREK-1 channel blockade and mood regulation for potential antidepressant drug discovery.
• Neuroprotection Studies: Research into the protective role of TREK-1 inhibition in models of ischemia and neurodegenerative diseases.
• Cardiac Electrophysiology: Investigation of TREK-1 channel function in atrial cardiomyocytes and its potential role in arrhythmias.
• High-Throughput Screening (HTS): Serves as a reference compound in assays designed to discover new TREK-1 modulators.

Basic Information

Product Name	Spadin
CAS No.	1270083-24-3
Molecular Formula	C23H21F3N2O3S
Molecular Weight	462.49 g/mol
Synonyms	Spadin; 3-(Trifluoromethyl)-N-[2-(4-methoxyphenyl)ethyl]-N-[(1R)-1-phenylethyl]-1-benzothiophene-2-carboxamide; (R)-3-(Trifluoromethyl)-N-(2-(4-methoxyphenyl)ethyl)-N-(1-phenylethyl)benzo[b]thiophene-2-carboxamide; TREK-1 Channel Blocker; Non-Peptide TREK-1 Antagonist
EINECS	Contact for details

Quality Control

Our Spadin is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.