Description

Txnip-In-1 CAS NO 1268955-50-5 is a potent and selective small-molecule inhibitor of the TXNIP protein, a key regulator of cellular redox signaling and glucose metabolism. This compound is a critical research tool for investigating the role of oxidative stress and metabolic dysfunction in various disease pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on metabolic disorders, cardiovascular disease, and oncology.

Application

• Biomedical Research: A key pharmacological tool for studying the TXNIP/thioredoxin pathway in cellular and animal models.
• Metabolic Disease Studies: Investigation of insulin resistance, type 2 diabetes, and diabetic complications by modulating cellular glucose uptake and oxidative stress.
• Cardiovascular Research: Exploration of its role in ischemia-reperfusion injury, cardiomyopathy, and atherosclerosis.
• Oncology Research: Probing the influence of TXNIP on tumor cell proliferation, apoptosis, and response to chemotherapy.
• Neurological Disorder Models: Used in research related to neurodegenerative diseases where oxidative stress is a contributing factor.
• Preclinical Drug Development: Serves as a reference compound or starting point for developing novel therapeutics targeting metabolic and redox-related diseases.

Basic Information

Product Name	Txnip-In-1
CAS No.	1268955-50-5
Molecular Formula	C₁₉H₁₉N₅O₂
Molecular Weight	349.39 g/mol
Synonyms	TXNIP Inhibitor, TXNIP-In-1; 4-(4-(4-Methoxyphenyl)-1H-imidazol-1-yl)-N-(pyridin-4-ylmethyl)benzamide; 4-[4-(4-Methoxyphenyl)-1H-imidazol-1-yl]-N-(4-pyridinylmethyl)benzamide; TXNIP inhibitor 1; Txnip-In-1; UNII-3W9U6Q5D6W
EINECS	Contact for details

Quality Control

Our Txnip-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to meet high-grade research standards. A detailed Certificate of Analysis (COA) with full characterization data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.