Description

(+)-Jq-1 CAS NO 1268524-70-4 is a potent, enantiomerically pure small molecule inhibitor of the bromodomain and extra-terminal (BET) family of proteins. This compound is a critical research tool for investigating epigenetic regulation, gene transcription, and their roles in disease pathology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, immunology, and inflammatory disease research.

Application

• Biochemical Research: A selective chemical probe for studying BET protein function and bromodomain-acetylated lysine interactions in vitro.
• Drug Discovery & Development: Used as a reference standard and lead compound in high-throughput screening and structure-activity relationship (SAR) studies for novel BET inhibitors.
• Oncology Research: Investigation of its effects on cancer cell proliferation, apoptosis, and MYC oncogene expression in various cancer models.
• Inflammation & Immunology Studies: Exploration of its role in modulating inflammatory cytokine production and immune cell activation pathways.
• Epigenetics & Transcriptional Regulation: Tool compound for dissecting the mechanisms of epigenetic readers in controlling gene expression programs.
• Veterinary Research: Potential application in comparative oncology studies for companion animals.

Basic Information

Product Name	(+)-Jq-1
CAS No.	1268524-70-4
Molecular Formula	C₂₃H₂₃ClN₄O₂S
Molecular Weight	454.97 g/mol
Synonyms	(+)-JQ1; JQ-1 (+)-enantiomer; (S)-JQ1; (S)-tert-Butyl 2-(4,4-dimethyl-2,6-dioxo-3-(tetrahydro-2H-pyran-4-yl)-1-piperidinyl)-4-(4-chlorophenyl)-5-methyl-3-thiophenecarboxylate; BET Inhibitor (+)-JQ1; BRD4 Inhibitor (+)-JQ-1; GTPL9799; HY-13030; BDBM50380895; SML0972; SR-2211; Thienotriazolodiazepine inhibitor (+)-JQ-1
EINECS	Contact for details

Quality Control

Our (+)-Jq-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our rigorous specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.