Description

Nilotinib-D6 CAS NO 1268356-17-7 is a deuterated isotopologue of the tyrosine kinase inhibitor nilotinib, where six hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug development and regulatory compliance for oncology therapeutics.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of nilotinib in biological matrices (plasma, serum, tissue).
• Facilitates pharmacokinetic (PK) and pharmacodynamic (PD) studies during clinical trials and preclinical research.
• Enables accurate drug metabolism and excretion (DMPK) studies to understand the metabolic profile of nilotinib.
• Supports bioequivalence and bioavailability testing for generic drug development.
• Used in forensic and anti-doping analysis for the detection and confirmation of nilotinib.
• Critical for method development and validation in GLP/GMP-compliant analytical laboratories.

Basic Information

Product Name	Nilotinib-D6
CAS No.	1268356-17-7
Molecular Formula	C28H16D6F3N7O
Molecular Weight	534.55 g/mol
Synonyms	4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide-d6; Nilotinib (hexadeuterated); AMN107-d6; Tasigna-d6; Nilotinib Internal Standard; Nilotinib-d6 (hexadeuterated, 98%); Deuterated Nilotinib; UNII-610417P7VH (deuterated form)
EINECS	Contact for details

Quality Control

Every batch of Nilotinib-D6 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, LC-MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and absence of critical impurities. Our quality commitment aligns with the standards expected for GMP/GLP laboratory use and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (deuterium enrichment)	≥98 atom % D
Chemical Purity (by HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.