Description

Ldn 193188 is a potent and selective small molecule inhibitor of the BMP (Bone Morphogenetic Protein) type I receptors ALK2 and ALK3. This compound is a critical research tool for studying BMP signaling pathways, which are fundamental to developmental biology, stem cell differentiation, and various disease states. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for target validation and mechanistic studies.

Application

• Biomedical Research: Essential for investigating the role of BMP signaling in embryonic development, tissue homeostasis, and cellular differentiation.
• Stem Cell Studies: Used to modulate BMP pathways to control the fate and differentiation of pluripotent and adult stem cells in vitro.
• Drug Discovery & Target Validation: Serves as a pharmacological tool to validate ALK2/ALK3 as therapeutic targets in preclinical models of fibrosis, heterotopic ossification, and certain cancers.
• Signal Transduction Analysis: Employed in biochemical and cellular assays to dissect downstream effects of BMP receptor inhibition.
• Academic & Institutional Laboratories: A key reagent for universities and research institutes conducting fundamental research in developmental and molecular biology.

Basic Information

Product Name	Ldn 193188
CAS No.	1267610-30-9
Molecular Formula	C₂₆H₂₆N₄O₃
Molecular Weight	442.51 g/mol
Synonyms	LDN-193188; LDN193188; DM-3189; 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline; BMP Inhibitor LDN 193188; ALK2/ALK3 Inhibitor; Dorsomorphin analog; BMP Type I Receptor Inhibitor
EINECS	Contact for details

Quality Control

Our Ldn 193188 is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical data, including HPLC chromatograms and NMR spectra. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.