Description

Bix02189 CAS NO 1265916-41-3 is a potent and selective small molecule inhibitor of the ERK5 (MAPK7) signaling pathway. This compound is a critical research tool for investigating cellular processes related to proliferation, differentiation, and survival. It is primarily utilized by researchers and developers in the fields of oncology, immunology, and neurodegenerative disease research. The high-purity material is essential for generating reliable and reproducible data in both in vitro and in vivo studies.

Application

• Biomedical Research: Fundamental research into the role of the ERK5 pathway in various cellular models.
• Oncology Studies: Investigation of cancer cell proliferation, metastasis, and as a potential lead compound for therapeutic development.
• Pharmacology & Drug Discovery: Used as a reference standard and a key reagent in high-throughput screening and target validation assays.
• Academic & Institutional Research: Supports studies in molecular biology, signal transduction, and disease mechanism elucidation.
• Biotech & Pharmaceutical R&D: Serves as a critical component in preclinical research for developing novel targeted therapies.

Basic Information

Product Name	Bix02189
CAS No.	1265916-41-3
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Bix 02189; BIX02189; BIX-02189; 5-[[(2S)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]-3-pyridinyl]methyl]-1,3-thiazolidine-2,4-dione; ERK5 Inhibitor II; MAPK7 Inhibitor
EINECS	Contact for details

Quality Control

Our Bix02189 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.