Description

1-Bromo-2,4-difluoro-3-(trifluoromethyl)benzene, also known as 3-bromo-alpha,alpha,alpha,2,6-pentafluorotoluene, is a highly fluorinated and halogenated aromatic building block of significant synthetic utility. Its unique structure, featuring both bromine and multiple fluorine substituents, makes it a valuable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and low surface energy properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations.
• Fluorinated Aromatic Chemistry Research: A critical reagent for academic and industrial R&D exploring new reactions and properties of perfluorinated aromatics.

Basic Information

Product Name	1-Bromo-2,4-difluoro-3-(trifluoromethyl)benzene
CAS No.	1263377-74-7
Molecular Formula	C7H2BrF5
Molecular Weight	260.99 g/mol
Synonyms	3-Bromo-alpha,alpha,alpha,2,6-pentafluorotoluene; 2-Bromo-1,3-difluoro-4-(trifluoromethyl)benzene; 1-Bromo-2,4-difluoro-3-(trifluoromethyl)benzene; 3-Bromo-2,4,6-trifluorobenzotrifluoride; 3-Bromo-2,4,6-trifluoro(trifluoromethyl)benzene; Benzene, 1-bromo-2,4-difluoro-3-(trifluoromethyl)-; Pentafluorotoluene, 3-bromo-
EINECS	Contact for details

Quality Control

Every batch of our 1-Bromo-2,4-difluoro-3-(trifluoromethyl)benzene is produced and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, NMR, and GC-MS to ensure identity, purity, and consistency meet the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its sensitivity to light, containers should be amber glass or otherwise light-protected.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.