Description

2,3-Difluoropyridine-4-Boronic Acid is a high-value organoboron building block, specifically a pyridine boronic acid derivative, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the creation of novel, fluorinated herbicides, fungicides, and insecticides with enhanced properties.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for introducing the difluoropyridine moiety into biaryl and heterobiaryl systems.
• Ligand and Catalyst Development: Precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as fluorinated semiconductors and light-emitting compounds.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological systems.

Basic Information

Product Name	2,3-Difluoropyridine-4-Boronic Acid
CAS No.	1263374-42-0
Molecular Formula	C5H4BF2NO2
Molecular Weight	158.90 g/mol
Synonyms	(2,3-Difluoropyridin-4-yl)boronic Acid; 4-Borono-2,3-difluoropyridine; 2,3-Difluoro-4-pyridineboronic Acid; 2,3-Difluoropyridine-4-boronic Acid Pinacol Ester (precursor); 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-difluoropyridine; 2,3-Difluoro-4-pyridinylboronic Acid; B-(2,3-Difluoro-4-pyridinyl)boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoropyridine-4-Boronic Acid undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process development. Our quality protocols are designed to support cGMP and ISO standards where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.