Description

m-Coumaric Acid-1,2,3-13C3 is a stable isotope-labeled analog of m-coumaric acid, where three carbon atoms in the aromatic ring are enriched with the non-radioactive carbon-13 isotope. This compound is essential as an internal standard for precise quantitative analysis in mass spectrometry-based metabolomic and pharmacokinetic studies. It is primarily used by researchers and manufacturers in the pharmaceutical, nutraceutical, and analytical chemistry industries to ensure accurate measurement of the native compound in complex biological matrices.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the accurate LC-MS/MS quantification of endogenous m-coumaric acid in plasma, serum, and tissue samples.
• Metabolic Pathway Tracing: Used in isotope dilution studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of phenolic acids in vivo.
• Pharmaceutical R&D: Enables precise bioanalysis during drug development for compounds derived from or interacting with coumaric acid pathways.
• Nutraceutical & Food Science: Facilitates the accurate assessment of bioavailability and bioactivity of m-coumaric acid from dietary supplements and functional foods.
• Quality Control & Method Validation: Employed in analytical laboratories to validate and calibrate HPLC and GC-MS methods for purity and potency testing.
• Clinical Research: Supports studies on the role of phenolic acids in oxidative stress, inflammation, and related health outcomes.

Basic Information

Product Name	m-Coumaric Acid-1,2,3-13C3
CAS No.	1262776-19-1
Molecular Formula	C613C3H8O3
Molecular Weight	185.15 g/mol (for 13C3 labeled form)
Synonyms	3-Hydroxycinnamic Acid-1,2,3-13C3; (E)-3-(3-Hydroxyphenyl)acrylic Acid-1,2,3-13C3; 3-Coumaric Acid-1,2,3-13C3; m-Hydroxycinnamic Acid-13C3; Isotopically Labeled m-Coumaric Acid; 13C3-m-Coumaric Acid; Internal Standard for m-Coumaric Acid
EINECS	Contact for details

Quality Control

Our m-Coumaric Acid-1,2,3-13C3 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is characterized by NMR and MS to confirm isotopic enrichment and positional labeling. Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity (typically ≥99 atom % 13C), chemical purity (by HPLC), and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % 13C)	≥99% on the labeled positions
Isotopic Enrichment (MS)	≥99% 13C3
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.