Description

Oxymetazoline-D4 is a deuterated analog of the well-known α-adrenergic agonist oxymetazoline, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and pharmacokinetic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise measurement of oxymetazoline and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering reference compound for the accurate quantification of oxymetazoline in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) profile of oxymetazoline in preclinical and clinical research.
• Bioanalytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Forensic Toxicology: Employed in confirmatory testing for the presence of oxymetazoline in forensic casework, ensuring high evidentiary standards.
• Clinical Research: Supports studies investigating the systemic exposure and safety profile of oxymetazoline-containing nasal decongestants or ophthalmic solutions.
• Metabolite Identification: Aids in the structural elucidation of oxymetazoline metabolites by providing a predictable mass shift in mass spectrometric analysis.

Basic Information

Product Name	Oxymetazoline-D4
CAS No.	1262053-60-0
Molecular Formula	C16H20D4N2O
Molecular Weight	260.40 g/mol
Synonyms	6-tert-Butyl-3-[(2-imino-3,4,5,6-tetradeutero-1-imidazolidinyl)methyl]-2,4-dimethylphenol; 2,4-Dimethyl-6-tert-butyl-3-[(4,5-dihydro-1H-imidazol-2-yl)(D4)methyl]phenol-D4; Deuterated Oxymetazoline; Oxymetazoline (phenyl-D4); Oxymetazoline-d4; [2H4]-Oxymetazoline
EINECS	Contact for details

Quality Control

Every batch of Oxymetazoline-D4 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR (1H, 13C) for structural confirmation and deuterium incorporation, and HPLC for chemical purity assessment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications and analytical results for your regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.