Description

3-Fluoro-5-Methoxypyridine-2-Sulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in its reactive sulfonyl chloride group, which enables efficient introduction of the sulfonamide moiety, a key pharmacophore in modern drug discovery. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in creating sulfonamide-based drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-containing drug candidates, including kinase inhibitors, antibacterial agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where the sulfonamide group enhances biological activity and selectivity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) to study enzyme function.
• Material Science Research: Employed in the creation of functionalized polymers and advanced materials with specific surface properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	3-Fluoro-5-Methoxypyridine-2-Sulfonyl Chloride
CAS No.	1261870-77-2
Molecular Formula	C6H5ClFNO3S
Molecular Weight	225.62 g/mol
Synonyms	2-Pyridinesulfonyl chloride, 3-fluoro-5-methoxy-; 3-Fluoro-5-methoxy-2-pyridinesulfonyl chloride; 3-Fluoro-5-methoxypyridine-2-sulfonyl chloride; 5-Methoxy-3-fluoropyridine-2-sulfonyl chloride; 1261870-77-2; 3-Fluoro-5-methoxy-pyridine-2-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-Methoxypyridine-2-Sulfonyl Chloride is produced and tested under a strict quality management system. We guarantee high chemical purity and consistency, with comprehensive analytical data provided for each lot. Certificates of Analysis (COA) detailing identity, purity (typically by HPLC/NMR), and impurity profiles are available upon request and are essential for your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.