Description

3-Bromo-2-Methoxypyridine-5-Sulfonyl Chloride is a high-value, multi-functional chemical building block primarily used in advanced organic synthesis. Its core value proposition lies in its dual functionality as both a halogenated heterocycle and a reactive sulfonyl chloride, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to construct pyridine-based herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the development of activity-based probes for target identification.
• Material Science: Employed in the creation of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Sulfonamide Library Synthesis: The reactive sulfonyl chloride group is ideal for high-throughput parallel synthesis to create diverse sulfonamide libraries for screening.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).

Basic Information

Product Name	3-Bromo-2-Methoxypyridine-5-Sulfonyl Chloride
CAS No.	1261858-64-3
Molecular Formula	C6H5BrClNO3S
Molecular Weight	286.53 g/mol
Synonyms	5-(Chlorosulfonyl)-3-bromo-2-methoxypyridine; 3-Bromo-2-methoxy-5-pyridinesulfonyl chloride; 2-Methoxy-3-bromopyridine-5-sulfonyl chloride; 3-Bromo-2-methoxypyridine-5-sulfonylchloride; 1261858-64-3; 3-Br-2-MeO-Py-5-SO2Cl
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Methoxypyridine-5-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.