Description

5-(Difluoromethyl)-2-Nitrotoluene is a specialized fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its core value lies in the strategic incorporation of both a difluoromethyl group and a nitro substituent on the toluene backbone, making it a versatile building block for the development of complex molecules. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials with unique electronic or surface properties.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to construct complex ligands for catalysis or molecular recognition applications.
• Fluorine Chemistry Studies: Acts as a model compound for investigating reactions and stability of difluoromethyl- and nitro- substituted aromatic systems under various conditions.

Basic Information

Product Name	5-(Difluoromethyl)-2-Nitrotoluene
CAS No.	1261851-70-0
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	2-Nitro-5-(difluoromethyl)toluene; 1-Methyl-2-nitro-5-(difluoromethyl)benzene; 5-(Difluoromethyl)-2-methylnitrobenzene; α,α-Difluoro-2-nitro-p-xylene; (Difluoromethyl)(2-methyl-5-nitrophenyl)methane
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethyl)-2-Nitrotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.