Description

5-Fluoro-2-Methoxypyridine-3-Sulfonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its value lies in its role as a versatile sulfonylation reagent, enabling the precise introduction of the sulfonyl chloride functional group into complex molecular architectures. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in the creation of sulfonamide-based drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing sulfonamide-based active pharmaceutical ingredients (APIs), including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require a sulfonyl moiety for bioactivity.
• Material Science Research: Employed in the development of specialty polymers and functional materials where sulfonamide linkages are desired for thermal or chemical stability.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies producing bespoke compounds for clients.

Basic Information

Product Name	5-Fluoro-2-Methoxypyridine-3-Sulfonyl Chloride
CAS No.	1261801-22-2
Molecular Formula	C6H5ClFNO3S
Molecular Weight	225.62 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 5-fluoro-2-methoxy-; 5-Fluoro-2-methoxy-3-pyridinesulfonyl chloride; 2-Methoxy-5-fluoropyridine-3-sulfonyl chloride; 1261801-22-2; 5-Fluoro-2-methoxypyridine-3-sulfonylchloride; 5-Fluoro-2-methoxy-pyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride, 5-fluoro-2-methoxy- (9CI)
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methoxypyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.