Description

1-(Bromomethyl)-3-Fluoro-5-Iodobenzene, also known as α-Bromo-3-Fluoro-5-Iodotoluene, is a high-value, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromomethyl, fluoro, and iodo substituents on a benzene ring, makes it a versatile intermediate for constructing complex molecules with precise electronic and steric properties. This compound is particularly critical for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients, as well as in materials science for creating specialized organic frameworks.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing halogenated benzyl groups into target molecules to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the halogen atoms are crucial for biological activity and binding affinity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis, leveraging the reactivity of the bromomethyl and iodo groups for functionalization.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to create tagged molecules or bioconjugates for imaging, diagnostics, and proteomics research due to its reactive handles.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) using the iodo and bromo functionalities.

Basic Information

Product Name	1-(Bromomethyl)-3-Fluoro-5-Iodobenzene
CAS No.	1261759-75-4
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	α-Bromo-3-Fluoro-5-Iodotoluene; 3-Fluoro-5-iodobenzyl Bromide; (3-Fluoro-5-iodophenyl)methyl Bromide; 1-Bromomethyl-3-fluoro-5-iodobenzene; α-Bromo-3-fluoro-5-iodotoluene; 3-Fluoro-α-bromo-5-iodotoluene; Benzene, 1-(bromomethyl)-3-fluoro-5-iodo-
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-3-Fluoro-5-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be performed under subdued lighting or in amber glass containers when possible.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.