Description

1-Chloro-4-Difluoromethyl-2-Iodobenzene, 97% is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the precise introduction of chlorine, iodine, and difluoromethyl groups into complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, fluorination chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or as handles for further functionalization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoromethyl and halogen groups can modulate physical properties and biological activity.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to form complex biaryl and other structures.
• Fluorine Chemistry: The difluoromethyl group (-CHF2) provides a metabolically stable and lipophilic bioisostere, making this compound valuable in medicinal chemistry for lead optimization.
• Chemical Biology & Diagnostics: Can be used to synthesize probes, tags, or labeling reagents for imaging and diagnostic applications.

Basic Information

Product Name	1-Chloro-4-Difluoromethyl-2-Iodobenzene, 97%
CAS No.	1261737-24-9
Molecular Formula	C7H4ClF2I
Molecular Weight	288.46 g/mol
Synonyms	2-Chloro-5-iodobenzotrifluoride (common misnomer); 4-Chloro-2-iodobenzylidene Difluoride; 1-Chloro-2-iodo-4-(difluoromethyl)benzene; 2-Iodo-5-chloro-α,α-difluorotoluene; Benzene, 1-chloro-4-(difluoromethyl)-2-iodo-; 1261737-24-9 (CAS Index Name)
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Difluoromethyl-2-Iodobenzene, 97% is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and FT-IR spectroscopy, to ensure it meets the specified grade and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical data is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.