Description

4-Chloro-2-Iodobenzene-1-Sulfonyl Chloride is a high-value, multi-functional aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated structure makes it an indispensable reagent for introducing the sulfonyl chloride functional group into complex molecules, enabling the creation of sulfonamides and other sulfonyl-based compounds. This intermediate is primarily sought after by pharmaceutical, agrochemical, and specialty chemical R&D laboratories for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel sulfonamide-based drug candidates, including potential enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides with sulfonyl urea or sulfonamide moieties.
• Material Science Research: Serves as a precursor for creating functional polymers, dyes, and liquid crystals with specific electronic or optical properties.
• Cross-Coupling Reactions: The iodine substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and affinity labels for studying protein function and enzyme activity.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	4-Chloro-2-Iodobenzene-1-Sulfonyl Chloride
CAS No.	1261730-58-8
Molecular Formula	C6H3Cl2IO2S
Molecular Weight	351.36 g/mol
Synonyms	2-Iodo-4-chlorobenzenesulfonyl chloride; 4-Chloro-2-iodobenzenesulfonyl chloride; 1-Chlorosulfonyl-4-chloro-2-iodobenzene; 4-Chloro-2-iodophenylsulfonyl chloride; Benzenesulfonyl chloride, 4-chloro-2-iodo-; (4-Chloro-2-iodophenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Iodobenzene-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization and purity verification. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition from atmospheric moisture. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.