Description

5-Methyl-2-(trifluoromethoxy)benzenesulfonyl chloride is a specialized aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the sulfonyl chloride group acts as a highly reactive electrophile for forming sulfonamides and sulfonate esters, while the trifluoromethoxy substituent imparts unique electronic and metabolic properties to the final molecule. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Material Science: Used in the development of specialty polymers and advanced materials with specific surface properties.
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and compound libraries.
• Ligand and Catalyst Development: Intermediate for constructing complex ligands used in catalytic systems.

Basic Information

Item	Detail
Product Name	5-Methyl-2-(Trifluoromethoxy)Benzenesulfonyl Chloride
CAS No.	1261683-44-6
Molecular Formula	C8H6ClF3O3S
Molecular Weight	274.65 g/mol
Synonyms	2-(Trifluoromethoxy)-5-methylbenzenesulfonyl chloride; 5-Methyl-2-(trifluoromethoxy)benzene-1-sulfonyl chloride; 1-Methyl-4-(trifluoromethoxy)benzene-2-sulfonyl chloride; α,α,α-Trifluoro-5-methyl-o-anisylsulfonyl chloride; 2-Methyl-5-(trifluoromethoxy)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-2-(trifluoromethoxy)benzenesulfonyl chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.