Description

1-(Bromomethyl)-3-Fluoro-2-Iodobenzene, also known as α-Bromo-3-Fluoro-2-Iodotoluene, is a high-value, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromomethyl, fluoro, and iodo substituents on a benzene ring, makes it a versatile and reactive intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, medicinal chemistry, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing fluorinated and iodinated drug candidates with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen atoms serve as handles for further functionalization to optimize biological activity.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine and bromine atoms are excellent substrates for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Negishi) to form new carbon-carbon bonds.
• Medicinal Chemistry & SAR Studies: Enables the rapid exploration of structure-activity relationships (SAR) by allowing selective modification at multiple sites on the aromatic core.
• Fluorine Chemistry: The presence of a fluorine atom makes it a valuable reagent for introducing fluorine into target molecules, a common strategy in modern drug design.

Basic Information

Product Name	1-(Bromomethyl)-3-Fluoro-2-Iodobenzene
CAS No.	1261675-04-0
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	α-Bromo-3-Fluoro-2-Iodotoluene; 2-Bromomethyl-6-Fluoro-1-Iodobenzene; 1-Bromomethyl-3-Fluoro-2-Iodobenzene; (3-Fluoro-2-iodophenyl)methyl Bromide; 3-Fluoro-2-iodobenzyl Bromide; α-Bromo-3-fluoro-2-iodotoluene; Benzene, 1-(bromomethyl)-3-fluoro-2-iodo-
EINECS	Contact for details

Quality Control

Our production of 1-(Bromomethyl)-3-Fluoro-2-Iodobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is characterized using advanced analytical techniques including NMR (1H, 13C, 19F), HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP and ISO standards for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.