Description

2-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride is a versatile and high-value aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a sulfonyl chloride and a nitrile group on a fluorinated benzene ring, makes it an essential reagent for introducing the 2-cyano-4-fluorobenzenesulfonyl moiety into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly sulfonamides and sulfonate esters. Its role is pivotal in creating compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfonamide functional groups with potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the sulfonyl moiety can contribute to biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of chemical probes to study enzyme activity and protein function.
• Dye & Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments, leveraging the electronic properties of the cyano and fluoro substituents.
• Custom Synthesis & Contract Manufacturing: A high-purity starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Item	Details
Product Name	2-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride
CAS No.	1261674-26-3
Molecular Formula	C7H3ClFNO2S
Molecular Weight	219.62 g/mol
Synonyms	4-Fluoro-2-cyanobenzenesulfonyl chloride; 2-Cyano-4-fluorobenzenesulfonyl chloride; 4-Fluoro-2-cyanobenzene-1-sulfonyl chloride; 1-(Chlorosulfonyl)-2-cyano-4-fluorobenzene; 2-Cyano-4-fluorophenylsulfonyl chloride; 4-Fluoro-2-(sulfonyl chloride)benzonitrile; Benzonitrile, 4-fluoro-2-(chlorosulfonyl)-
EINECS	Contact for details

Quality Control

Our 2-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.