Description

1-Fluoro-3-(Difluoromethyl)-2-Iodobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring fluorine, iodine, and a difluoromethyl group, makes it a versatile intermediate for introducing specific functionalities into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the production of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution patterns on molecular conformation, lipophilicity, and biological activity.
• Diagnostic Agent Development: Potential use as a building block for radiolabeled compounds (e.g., for PET imaging) due to the presence of halogens suitable for isotopic exchange.

Basic Information

Product Name	1-Fluoro-3-(Difluoromethyl)-2-Iodobenzene
CAS No.	1261647-51-1
Molecular Formula	C7H4F3I
Molecular Weight	295.91 g/mol
Synonyms	2-Iodo-1-fluoro-3-(difluoromethyl)benzene; 3-(Difluoromethyl)-1-fluoro-2-iodobenzene; 1-Fluoro-2-iodo-3-(difluoromethyl)benzene; Benzene, 1-fluoro-3-(difluoromethyl)-2-iodo-; 2-Fluoro-6-(difluoromethyl)iodobenzene; (Difluoromethyl)(2-fluoro-6-iodophenyl)methane
EINECS	Contact for details

Quality Control

Our 1-Fluoro-3-(Difluoromethyl)-2-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.