Description

2-(Difluoromethoxy)-5-(3-(Trifluoromethyl)Phenyl)Pyridine is a high-value fluorinated pyridine derivative, a key structural motif prized for its ability to modulate the physicochemical properties of advanced molecules. Its primary commercial value lies in serving as a sophisticated pharmaceutical intermediate and agrochemical building block, where the introduction of fluorine atoms is critical for enhancing metabolic stability, bioavailability, and target binding affinity. This compound is essential for R&D and production teams in life sciences and specialty chemical sectors developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug discovery pipelines.
• Agrochemical Synthesis: Used as a building block for developing advanced herbicides, fungicides, and insecticides, where the fluorinated structure contributes to efficacy and environmental profile.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties imparted by the fluorine substituents.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds used in target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A key starting material for fine chemical manufacturers offering bespoke synthesis services to the pharmaceutical and agrochemical industries.

Basic Information

Product Name	2-(Difluoromethoxy)-5-(3-(Trifluoromethyl)Phenyl)Pyridine
CAS No.	1261628-34-5
Molecular Formula	C13H8F5NO
Molecular Weight	289.20 g/mol
Synonyms	5-[3-(Trifluoromethyl)phenyl]-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-[3-(trifluoromethyl)phenyl]pyridine; 2-Difluoromethoxy-5-(3-trifluoromethylphenyl)pyridine; Pyridine, 2-(difluoromethoxy)-5-[3-(trifluoromethyl)phenyl]-; DFM-TFMP-Pyridine
EINECS	Contact for details

Quality Control

Our production of 2-(Difluoromethoxy)-5-(3-(Trifluoromethyl)Phenyl)Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for advanced synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your regulatory and quality documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.