Description

1-Bromo-2-Chloro-4-(Difluoromethyl)Benzene is a high-value halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring difluoromethyl and halogenated aryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination to form biaryl structures.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	1-Bromo-2-Chloro-4-(Difluoromethyl)Benzene
CAS No.	1261614-16-7
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	2-Chloro-1-bromo-4-(difluoromethyl)benzene; 4-Bromo-3-chlorobenzylidene difluoride; 4-(Difluoromethyl)-1-bromo-2-chlorobenzene; 1-Bromo-2-chloro-4-difluoromethylbenzene; Benzene, 1-bromo-2-chloro-4-(difluoromethyl)-; 3-Chloro-4-bromobenzylidene difluoride
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-4-(Difluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended long-term storage temperature is between 2°C and 8°C. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.