Description

5-Hydroxy-2-(trifluoromethoxy)benzaldehyde is a specialized aromatic aldehyde building block featuring both a phenolic hydroxyl group and a trifluoromethoxy substituent. This unique molecular structure makes it a valuable intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced lipophilicity and metabolic stability are required. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and advanced material science industries for creating novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research, where the trifluoromethoxy group can improve bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the chemical and thermal stability imparted by the fluorine atoms.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated aromatic cores in advanced electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Incorporated into polymer backbones or as a functional end-group to alter material properties such as solubility, thermal stability, and surface energy.
• Complex Ligand & Catalyst Development: Utilized in organometallic chemistry to create sophisticated ligands for catalysis, benefiting from the electron-withdrawing nature of the trifluoromethoxy group.
• Fluorescent Probe & Dye Chemistry: Acts as a starting material for synthesizing fluorophores and molecular probes used in bioimaging and diagnostic assays.

Basic Information

Item	Details
Product Name	5-Hydroxy-2-(Trifluoromethoxy)Benzaldehyde
CAS No.	1261584-14-8
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	5-Hydroxy-2-(trifluoromethoxy)benzaldehyde; 2-Trifluoromethoxy-5-hydroxybenzaldehyde; 5-Hydroxy-α,α,α-trifluoro-o-anisaldehyde; Salicylaldehyde, 5-hydroxy-2-(trifluoromethoxy)-; Benzaldehyde, 5-hydroxy-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-2-(trifluoromethoxy)benzaldehyde is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.