Description

2-Chloro-4-(Trifluoromethoxy)Benzyl Chloride is a versatile and high-value organofluorine building block essential for advanced chemical synthesis. Its bifunctional structure, featuring both a reactive benzyl chloride group and a stable trifluoromethoxy substituent, makes it a critical intermediate for introducing specific pharmacophores and agrochemical motifs. This compound is primarily sought after by R&D and process chemists in the pharmaceutical and agrochemical industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Material Development: Intermediate for creating specialty polymers, coatings, and advanced materials with specific chemical resistance or surface properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for constructing complex biaryl systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethoxy)Benzyl Chloride
CAS No.	1261581-56-9
Molecular Formula	C8H5Cl2F3O
Molecular Weight	245.03 g/mol
Synonyms	1-(Chloromethyl)-2-chloro-4-(trifluoromethoxy)benzene; α,2-Dichloro-4-(trifluoromethoxy)toluene; 2-Chloro-α-(chloromethyl)-4-(trifluoromethoxy)benzene; (2-Chloro-4-(trifluoromethoxy)phenyl)methyl chloride; Benzene, 1-(chloromethyl)-2-chloro-4-(trifluoromethoxy)-; 2-Chloro-4-trifluoromethoxybenzyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(Trifluoromethoxy)Benzyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency essential for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its reactivity as an organic halide, it should be stored separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.