Description

2-Cyano-5-Methoxybenzene-1-Sulfonyl Chloride is a high-value sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual reactive sites—the sulfonyl chloride and cyano groups—which enable efficient derivatization for creating complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with sulfonyl urea or sulfonamide moieties.
• Material Science Research: Used in the development of specialty polymers, dyes, and functional materials requiring sulfonyl linkages.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.
• Academic & R&D Laboratories: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Item	Detail
Product Name	2-Cyano-5-Methoxybenzene-1-Sulfonyl Chloride
CAS No.	1261573-04-9
Molecular Formula	C8H6ClNO3S
Molecular Weight	231.66 g/mol
Synonyms	5-Methoxy-2-cyanobenzenesulfonyl chloride; 2-Cyano-5-methoxybenzenesulfonyl chloride; 5-Methoxy-2-cyanophenylsulfonyl chloride; 2-Cyano-5-methoxyphenylsulfonyl chloride; 1-(Chlorosulfonyl)-5-methoxy-2-cyanobenzene; 1261573-04-9; 5-Methoxy-2-cyano-benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Cyano-5-Methoxybenzene-1-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.