Description

2-Chloro-3,5-Difluorobenzaldehyde is a versatile fluorinated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of halogen and fluorine substituents, which enable precise molecular modifications and the introduction of unique physicochemical properties into target compounds. This intermediate is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorobenzene core with an aldehyde handle for further derivatization.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the chloro and difluoro groups can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic components in electronic and display materials, influencing dielectric anisotropy and emission properties.
• Cross-Coupling Reactions: The aldehyde group and halogenated aromatic ring make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).
• Organic Ligand Preparation: Utilized for synthesizing specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke synthesis projects requiring fluorinated aromatic aldehydes.

Basic Information

Product Name	2-Chloro-3,5-Difluorobenzaldehyde
CAS No.	1261561-82-3
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	2-Chloro-3,5-difluorobenzaldehyde; 3,5-Difluoro-2-chlorobenzaldehyde; Benzaldehyde, 2-chloro-3,5-difluoro-; 2-Chloro-3,5-difluoro-benzaldehyde; 1261561-82-3
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3,5-Difluorobenzaldehyde undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of research and industrial-scale customers. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), identity (by IR/NMR), and impurity profile is provided with each shipment to guarantee reliable and reproducible performance in your synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.