Description

Olumacostat Glasaretil is a synthetic small molecule inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme in fatty acid synthesis. This compound is of significant interest for its targeted mechanism of action in regulating lipid metabolism. It is primarily utilized in advanced pharmaceutical research and development, particularly for investigating therapeutic pathways related to metabolic and dermatological conditions.

Application

• Pharmaceutical R&D as a lead compound for metabolic disorder therapeutics.
• Biochemical Research tool for studying the role of ACC in de novo lipogenesis.
• Investigation of potential treatments for non-alcoholic fatty liver disease (NAFLD) and related syndromes.
• Exploratory studies for acne vulgaris and other sebum-driven dermatological conditions.
• Pre-clinical development of lipid-lowering agents.
• Use in mechanism-of-action studies and target validation within metabolic pathways.

Basic Information

Product Name	Olumacostat Glasaretil
CAS No.	1261491-89-7
Molecular Formula	C₂₉H₄₀N₄O₅
Molecular Weight	524.66 g/mol
Synonyms	NDI 010976; PF-05221304; Olumacostat glasaretil; (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic Acid (2S)-1-[(2S)-2-{[5-(2,2-Dimethylpropanoyl)-2-pyridinyl]oxy}-1-oxo-3-phenylpropyl]-2-pyrrolidinyl Ester; ACC Inhibitor ND-010976; Glasaretil, Olumacostat
EINECS	Contact for details

Quality Control

Our Olumacostat Glasaretil is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. All materials are supported by comprehensive analytical data. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.