Description

1-Bromo-3-(Difluoromethoxy)-2-Methylbenzene is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and fluorinated aromatic structure. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), where it serves as a versatile building block for introducing specific bromine and difluoromethoxy functional groups. Pharmaceutical, agrochemical, and specialty chemical R&D teams need it to develop new molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for introducing bromine and difluoromethoxy substituents.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoromethoxy group can improve compound efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and material science applications.
• Fluorinated Compound Research: Essential for academic and industrial R&D focused on synthesizing and studying new fluorinated aromatic compounds.
• Custom Synthesis Projects: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis and scale-up projects.

Basic Information

Product Name	1-Bromo-3-(Difluoromethoxy)-2-Methylbenzene
CAS No.	1261475-57-3
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-Methyl-1-bromo-3-(difluoromethoxy)benzene; 3-Bromo-2-methylphenyl difluoromethyl ether; Benzene, 1-bromo-3-(difluoromethoxy)-2-methyl-; 1-Bromo-3-(difluoromethoxy)-2-methyl-benzene; 2-Methyl-3-(difluoromethoxy)bromobenzene; 3-(Difluoromethoxy)-2-methylbromobenzene; (2-Methyl-3-bromophenyl) difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Difluoromethoxy)-2-Methylbenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.