Description

5-Chloro-2-Methoxypyridine-3-Sulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its value lies in its dual reactive sites, the sulfonyl chloride and the halogenated pyridine ring, which enable efficient derivatization and the construction of complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its heterocyclic core.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology Probe Development: Employed to create sulfonamide-based probes and ligands for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Research & Development: Fundamental reagent in academic and industrial R&D labs for exploring new chemical reactions and synthesizing novel compound libraries.

Basic Information

Product Name	5-Chloro-2-Methoxypyridine-3-Sulfonyl Chloride
CAS No.	1261451-92-6
Molecular Formula	C6H5Cl2NO3S
Molecular Weight	250.08 g/mol
Synonyms	3-Chlorosulfonyl-5-chloro-2-methoxypyridine; 5-Chloro-2-methoxy-3-pyridinesulfonyl chloride; 2-Methoxy-5-chloropyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride, 5-chloro-2-methoxy-; 1261451-92-6
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Methoxypyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.