Description

2-Bromo-5-Methylbenzodifluoride is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic combination of a bromine substituent, which facilitates cross-coupling reactions, with the difluoromethyl group, a key motif for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: Essential for academic and industrial research focused on incorporating fluorine atoms into organic molecules to study structure-activity relationships.
• Dye and Pigment Intermediate: Employed in the synthesis of novel fluorinated dyes and pigments with enhanced properties like light fastness and color intensity.

Basic Information

Item	Details
Product Name	2-Bromo-5-Methylbenzodifluoride
CAS No.	1261442-36-7
Molecular Formula	C8H5BrF2
Molecular Weight	219.03 g/mol
Synonyms	1-Bromo-4-(difluoromethyl)-2-methylbenzene; 2-Bromo-α,α-difluoro-p-xylene; 4-Bromo-2-methylbenzodifluoride; 2-Methyl-5-bromobenzodifluoride; 5-Bromo-2-methylbenzodifluoride; (2-Bromo-5-methylphenyl)difluoromethane
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Methylbenzodifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.