Description

Cyclobenzaprine-D6 CAS NO 1261396-60-4 is a deuterated analog of the centrally-acting skeletal muscle relaxant, cyclobenzaprine, where six hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities for drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and clinical trial sample analysis.

Application

• Internal standard for the precise quantification of cyclobenzaprine in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS.
• Critical reagent in bioanalytical method development and validation for regulatory submissions to agencies like the FDA and EMA.
• Use in drug metabolism studies (ADME) to track the pharmacokinetic profile of the parent drug.
• Essential for high-accuracy testing in clinical trials and therapeutic drug monitoring (TDM).
• Quality control and assurance in pharmaceutical manufacturing of cyclobenzaprine-based products.
• Forensic and toxicology analysis for the definitive identification and measurement of cyclobenzaprine.

Basic Information

Product Name	Cyclobenzaprine-D6
CAS No.	1261396-60-4
Molecular Formula	C20H15D6N
Molecular Weight	279.42 g/mol
Synonyms	Cyclobenzaprine-d6; 5-(3-Dibenzocycloheptenylidene)-1,1,2,2,3,3-hexadeutero-N,N-dimethyl-1-propanamine; Amrix-d6; Fexmid-d6; Flexeril-d6; 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine-d6; Deuterated Cyclobenzaprine
EINECS	Contact for details

Quality Control

Our Cyclobenzaprine-D6 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical stability. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and mass spectrometry. We guarantee compliance with the stringent requirements for stable isotope-labeled compounds used in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions after opening to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.