Description

[13C7]-L-3,4-Dihydroxyphenylserine Hydrochloride is a stable isotope-labeled derivative of L-DOPS, a synthetic amino acid precursor to norepinephrine. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers for pharmacokinetic studies, metabolic pathway analysis, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of L-DOPS and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and non-clinical research.
• Metabolic Pathway Tracing: Used in isotope dilution studies to investigate the biosynthesis and catabolism of catecholamines.
• Bioanalytical Method Development and Validation: Serves as a reference standard to establish specificity, accuracy, and precision of analytical assays.
• Drug Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradants in active pharmaceutical ingredient (API) batches.
• Neurochemical Research: Supports fundamental research into norepinephrine synthesis, storage, and release mechanisms.

Basic Information

Product Name	[13C7]-L-3,4-Dihydroxyphenylserine Hydrochloride
CAS No.	1261393-39-8
Molecular Formula	C913C7H14NO6 • HCl
Molecular Weight	Contact for details
Synonyms	L-[13C7]-DOPS HCl; (2S,3R)-2-Amino-3-(3,4-dihydroxy[13C7]phenyl)-3-hydroxypropanoic Acid Hydrochloride; [13C7]-L-Threo-DOPS Hydrochloride; Carbon-13 Labeled L-Droxidopa HCl; Stable Isotope-Labeled L-DOPS; [13C7]-L-Dihydroxyphenylserine HCl; [13C7]-L-Threodops Hydrochloride; Northera Internal Standard ([13C7])
EINECS	Contact for details

Quality Control

Every batch of [13C7]-L-3,4-Dihydroxyphenylserine Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, isotopic enrichment, and residual solvents are provided to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.