Description

Paclitaxel-D5 (Benzoyloxy) is a deuterated analog of the potent antineoplastic agent paclitaxel, specifically labeled on the benzoyloxy group. This stable isotope-labeled compound is an essential reference standard and internal standard for the precise quantification and metabolic profiling of paclitaxel in complex biological matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in bioanalytical method development, pharmacokinetic studies, and drug metabolism research.

Application

• Bioanalytical Reference Standard: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods for the accurate quantification of paclitaxel in plasma, serum, and tissue samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in metabolic stability studies, absorption, distribution, metabolism, and excretion (ADME) research, and metabolite identification to track the parent drug without interference from endogenous compounds.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables precise measurement of paclitaxel concentrations in patient samples to optimize dosing regimens, minimize toxicity, and enhance therapeutic efficacy.
• Pharmaceutical Quality Control: Acts as a certified reference material for the assay and impurity profiling of paclitaxel in active pharmaceutical ingredient (API) and finished drug product analysis.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy analytical techniques for the definitive measurement of paclitaxel, ensuring traceability and meeting rigorous regulatory standards.

Basic Information

Product Name	Paclitaxel-D5 (Benzoyloxy)
CAS No.	1261254-56-1
Molecular Formula	C47H46D5NO14
Molecular Weight	~ 858.9 g/mol
Synonyms	Paclitaxel (benzoyl-D5); Paclitaxel-d5 (Benzoyl-2H5); Taxol-d5 (Benzoyloxy); (2α,4α,5β,7β,10β,13α)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-(benzoyl-D5)amino]-2-hydroxy-3-phenylpropanoyl}oxy]-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; Deuterated Paclitaxel (Benzoyloxy); Paclitaxel Internal Standard (d5-Benzoyl); Stable Isotope-Labeled Paclitaxel
EINECS	Contact for details

Quality Control

Our Paclitaxel-D5 (Benzoyloxy) is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is comprehensively characterized using techniques including NMR (¹H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm identity, chemical purity, and isotopic purity (typically ≥98 atom % D). Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (HRMS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.